Overview

• Trent Williams, the 49ers' star left tackle, has been officially ruled out for Sunday's game due to an ankle injury that has sidelined him since Week 11.
• Defensive end Nick Bosa, dealing with an oblique injury, is listed as doubtful and will be a game-time decision after limited progress in practice this week.
• The 49ers have struggled without Williams and Bosa, holding a winless 0-5 record when both players are absent, including two recent losses by a combined score of 73-20.
• San Francisco's playoff hopes are in jeopardy, as a loss to the Bears would drop them three games below .500, making a postseason push highly unlikely.
• The Bears also face injury concerns, with key players like running back D’Andre Swift and wide receiver D.J. Moore listed as questionable for Sunday’s matchup.