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49ers Enter Preseason With Full-Strength Offense and Depth Battles

San Francisco’s preseason roster is set ahead of Saturday’s opener against Denver with its core offensive stars in full health.

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Denver Broncos vs San Francisco 49ers - NFL Preseason Week 1
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Overview

  • Christian McCaffrey and Trent Williams, each limited by injury in 2024, are fully cleared and expected to play key roles as the team opens its preseason.
  • Quarterback Brock Purdy’s five-year, $265 million extension provides long-term stability under center after signing in May.
  • Analysts rate San Francisco’s 2025 slate as the NFL’s easiest based on last season’s standings, heightening expectations for a divisional rebound.
  • Training camp developments included rookie Mykel Williams earning a positive evaluation after a joint practice scare, the re-signing of QB Tanner Mordecai, and wide receiver Equanimeous St. Brown moving to injured reserve.
  • CBS Sports’ Tyler Sullivan tags the wide receiver room as a top wildcard, while Bleacher Report’s Moe Moton projects a 12-5 record and an NFC West title for the 49ers.