Overview

• Coordinator Robert Saleh has installed up to eight new starters, blending rookie talent with veteran anchors Nick Bosa and Fred Warner.
• Mykel Williams, Alfred Collins, C.J. West, Upton Stout and Nick Martin are trending toward significant roles after standout training camp performances.
• Thursday’s joint practice against the Broncos will be the first time the defense faces an unfamiliar opponent without prior preparation.
• Saleh cautioned that real proof of the rookies’ readiness will come when tackling becomes live across three preseason games.
• By using their first five picks of the 2025 draft on defensive prospects for the first time in 44 years, the 49ers signaled a rapid youth-driven overhaul.