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49ers Deem Brock Purdy 'Highly Unlikely' to Start vs. Cardinals, Mac Jones Poised to Play

A Saturday decision follows a limited practice week, with Adrian Martinez a possible elevation for depth.

Sep 14, 2025; New Orleans, Louisiana, USA; San Francisco 49ers quarterback Mac Jones (10) passes against the New Orleans Saints during the second half at Caesars Superdome. Mandatory Credit: Stephen Lew-Imagn Images/File Photo
FILE pHOTO: Sep 7, 2025; Seattle, Washington, USA; San Francisco 49ers quarterback Brock Purdy (13) looks on during the first half against the Seattle Seahawks at Lumen Field. Mandatory Credit: Joe Nicholson-Imagn Images/File Photo
San Francisco 49ers quarterback Brock Purdy looks at a Microsoft Surface tablet during the game against the Seahawks on Sunday, Sept. 7, 2025 in Seattle.
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Overview

  • Purdy was officially listed as questionable on Friday after practicing on a limited basis throughout the week.
  • An MRI described his toe injury as similar to turf toe and not requiring surgery, and he already missed last week’s game.
  • San Francisco must determine Saturday whether Purdy will be the No. 2 or the emergency third quarterback, a choice that would require elevating Adrian Martinez if Purdy is inactive or designated emergency only.
  • If Purdy does not start, Mac Jones is in line for a second consecutive start after completing 26 of 39 passes for 279 yards and three touchdowns in the Week 2 win at New Orleans.
  • Jauan Jennings (ankle, shoulder) and Connor Colby (groin) are questionable, while Spencer Burford (knee) and Jordan Watkins (calf) are out, with Watkins a potential IR move and surgery possible for Burford.