Overview
- San Francisco moved to 11-4 and a five-game winning streak with a 48-27 road win over the Colts in Week 16.
- The Week 17 task is clear: beat the Bears to stay on a win‑out track, then defeat the Seahawks in Week 18 to clinch the top NFC seed according to current tiebreakers.
- Tight end George Kittle sustained a mid-to-low ankle sprain, did not practice Wednesday or Thursday, and is considered week to week with a reported chance to face Chicago.
- Quarterback Brock Purdy was named NFC Offensive Player of the Week after throwing five touchdowns against Indianapolis.
- Injuries have pressed younger defenders into starting roles, the team added quarterback Adrian Martinez to the practice squad, and Brandon Aiyuk remains out for the season on the reserve/left squad list.