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49ers Camp Injuries Strain Running Back and Defensive Line Depth

Extended absences for backups behind Christian McCaffrey have pushed rookies into prominent roles.

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Jun 10, 2025; Santa Clara, CA, USA; San Francisco 49ers head coach Kyle Shanahan watches his players work out during an OTA at Levi's Stadium. Mandatory Credit: D. Ross Cameron-Imagn Images

Overview

  • Christian McCaffrey remains the only proven running back as Isaac Guerendo’s shoulder injury sidelines him for several weeks.
  • Rookie Jordan James returned to practice Monday after a minor knee issue kept him out of drills.
  • Patrick Taylor Jr. has stepped up as the primary backup in a backfield thinned by trades and early camp injuries.
  • Defensive tackle Kevin Givens will miss an extended period with a pec injury while edge rusher Yetur Gross-Matos is expected back next week.
  • Newly signed wide receiver Andy Isabella will miss multiple weeks with an ankle injury and safety Ji’Ayir Brown could resume practice later this week after an ankle flare-up.