Overview

• Kickoff is set for Sunday at 4:25 p.m. ET at Raymond James Stadium, with CBS carrying the broadcast.
• Both teams are 4-1, and betting markets make Tampa Bay a small home favorite with a spread around three points.
• San Francisco expects Brock Purdy to be out, making Mac Jones the likely starter despite knee and oblique issues after throwing for 342 yards in an overtime win at the Rams.
• The 49ers’ offense remains shorthanded with George Kittle sidelined, Ricky Pearsall dealing with a knee issue, and Jauan Jennings listed as questionable.
• Tampa Bay is without wide receivers Mike Evans and Chris Godwin, yet Baker Mayfield enters off a 379-yard, two-touchdown outing as rookie Emeka Egbuka continues a fast start with 25 catches for 445 yards and five touchdowns through five games.