Overview

• Both teams enter Week 6 at 4-1 and tied for the NFL’s best record, with FanDuel listing the Buccaneers as a three-point home favorite at Raymond James Stadium.
• San Francisco leads the league in passing but ranks near the bottom in rushing, raising pressure to finish drives with touchdowns rather than field goals.
• Analysts highlight Vita Vea versus 49ers guard Dominick Puni as a pivotal interior battle that could bottle up Christian McCaffrey and force longer third downs.
• Tampa Bay’s offense has been productive through five weeks, ranking seventh in points, with Baker Mayfield playing one of the strongest stretches of his career.
• Availability looms large with Tampa Bay’s secondary dealing with injuries to Jamel Dean and Zyon McCollum’s thumb procedure, Tristan Wirfs back at tackle, and San Francisco’s pass rush impacted by Nick Bosa’s injury history against Bowles-led teams.