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49ers Beat Panthers 20-9 on MNF as Defense and McCaffrey Offset Purdy's Turnovers

Key defensive plays with a heavy Christian McCaffrey workload steadied San Francisco despite three first-half interceptions.

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Jauan Jennings (L) is separated from Tre'von Moehrig (R) after the game.
SANTA CLARA, CALIFORNIA - NOVEMBER 24: Christian McCaffrey #23 of the San Francisco 49ers runs into the end zone for a touchdown in the third quarter of the game against the Carolina Panthers at Levi's Stadium on November 24, 2025 in Santa Clara, California. (Photo by Thien-An Truong/Getty Images)
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Overview

  • Brock Purdy threw three interceptions before halftime and finished 23-of-32 for 193 yards with one touchdown, putting ball security back under scrutiny.
  • Safety Ji'Ayir Brown intercepted Bryce Young twice as San Francisco held Carolina to 230 yards and just three points off three 49ers turnovers.
  • Christian McCaffrey logged 31 touches for 142 yards and a score against his former team, continuing his workhorse pace in the 49ers offense.
  • San Francisco improved to 8-4 to strengthen its NFC wild-card position, while Carolina fell to 6-6 and squandered a chance to take the NFC South lead.
  • Postgame tensions flared after Panthers safety Tre'von Moehrig struck Jauan Jennings in the groin, an incident Kyle Shanahan called a cheap shot that drew league attention, as Carolina also reported multiple injuries including Jaycee Horn's concussion.