Overview
- Kickoff is set for Sunday, Nov. 16 at 4:05 p.m. ET on FOX from State Farm Stadium in Glendale.
- San Francisco enters at 6-4 after a 42-26 loss to the Rams, while Arizona is 3-6.
- Kyler Murray is on injured reserve with a foot injury, and Jacoby Brissett has gone 1-3 in four starts.
- Opening lines list the 49ers around -1.5 on the spread with a -122 moneyline, and USA TODAY panelists picked San Francisco to cover (mostly at -2.5).
- Team analysts frame this as the start of a four-game stretch the 49ers need to sweep to solidify playoff positioning.