Overview
- San Francisco lists seven inactives: Robert Beal Jr., Kevin Givens, Isaac Guerendo, Chase Lucas, Ricky Pearsall, Trent Williams, and Curtis Robinson.
- George Kittle is available despite a recent ankle issue after entering the game as questionable.
- Trent Williams (hamstring) did not practice this week, with Ricky Pearsall (knee/ankle) limited before both were ruled out.
- Seattle designates quarterback Jalen Milroe inactive as the emergency third option, with Charles Cross (hamstring) and Coby Bryant (knee) also inactive.
- Offensive lineman Josh Jones is dressed for the 49ers after being listed as questionable.