Overview

• The San Francisco 49ers' 2025 schedule was officially unveiled, with the team opening on Sept. 7 against division rival Seattle Seahawks.
• The 49ers are projected to have the easiest schedule in the league, based on opponents' 2024 records (.415 winning percentage).
• San Francisco will play five primetime games, including two Monday night, two Sunday night, and one Thursday night matchup.
• The schedule includes all NFC South and AFC South teams, plus non-divisional games against the Bears, Browns, and Giants.
• USA TODAY predicts an 11-6 finish for the 49ers, reflecting optimism around offseason roster improvements and the favorable schedule.