Overview

• The approach combines 3D printing, stem cell biology, and organoid scaffolds with microscopic channels seeded with region-specific spinal neural progenitor cells.
• In rats with complete spinal cord transections, the implant promoted bidirectional axon growth and integration with host circuits, producing measurable motor recovery.
• Researchers describe the construct as a relay that can bypass damaged tissue by directing new nerve fibers to bridge the injury site.
• The findings are published in Advanced Healthcare Materials, with support from the NIH, Minnesota’s SCI/TBI research grant program, and the Spinal Cord Society.
• The team plans to scale production and advance toward clinical development, noting the work remains early-stage with no human data yet and a large unmet need in SCI care.