St. Francois County is a county in the Lead Belt region in the U.S. state of Missouri. At the 2020 census, the population was 66,922. The largest city and county seat is Farmington. The county was officially organized on December 19, 1821. It was named after the St. Francis River. The origin of the river's name is unclear. It may refer to St. Francis of Assisi. From Wikipedia
