SWISS-MODEL is a structural bioinformatics web-server dedicated to homology modeling of 3D protein structures. Homology modeling is currently the most accurate method to generate reliable three-dimensional protein structure models and is routinely used in many practical applications. Homology (or comparative) modelling methods make use of experimental protein structures ("templates") to build models for evolutionary related proteins ("targets"). Today, SWISS-MODEL consists of three tightly integrated components: (1) The SWISS-MODEL pipeline – a suite of software tools and databases for automated protein structure modelling, (2) The SWISS-MODEL Workspace – a web-based graphical user workbench, (3) The SWISS-MODEL Repository – a continuously updated database of homology models for a set of model organism proteomes of high biomedical interest.
