The Ellen DeGeneres Show is an American first-run syndicated talk show that was hosted by Ellen DeGeneres. The show ran for nineteen seasons from September 8, 2003, to May 26, 2022, in which it broadcast 3,339 episodes. From Wikipedia
In his latest Netflix monologue, Mulaney humorously likens raising his 3-year-old son to the high-energy unpredictability of Ellen DeGeneres' talk show, referencing its controversial workplace culture.