Amy Farrah Fowler, Ph.D. is a fictional character in the CBS television series The Big Bang Theory, portrayed by Mayim Bialik. Amy is a neuroscientist who is the love interest of Sheldon Cooper and subsequent wife in the series. From Wikipedia
Chuck Lorre and Peter Roth discuss how Kaley Cuoco's character grew beyond the 'dumb blonde' trope to become a multidimensional figure central to the sitcom's success.