The 2022 United States Senate election in Missouri was held on November 8, 2022, concurrently with elections for all other Class 3 U.S. senators and elections for the U.S. House of Representatives, to select a member of the United States Senate to represent the state of Missouri. Incumbent Republican Senator Roy Blunt announced that he would not seek reelection to a third term in office. Missouri Attorney General Eric Schmitt won the election to succeed him. Anheuser-Busch heiress Trudy Busch Valentine won the Democratic primary. John Wood, a former Bush administration official and a January 6 Committee investigator, announced that he would run for the seat as an independent on June 29, but he withdrew from the race after former Missouri Governor Eric Greitens lost the Republican primary to Schmitt. Schmitt subsequently won the election, albeit by a slightly reduced margin from Trump in 2020, though also far greater than by the percentage Blunt defeated Jason Kander 6 years prior.
