The Super Regional round of the 2021 NCAA Division I baseball tournament were eight best-of-three-games series to determine the participating teams of the 2021 College World Series. These matchups were:
Arkansas Razorbacks vs. NC State Wolfpack: NC State wins series 2–1.
Texas Tech Red Raiders vs. Stanford Cardinal: Stanford wins series 2–0.
Arizona Wildcats vs. Ole Miss Rebels: Arizona wins series 2–1.
Vanderbilt Commodores vs. East Carolina Pirates: Vanderbilt wins series 2–0.
Texas Longhorns vs. South Florida Bulls: Texas wins series 2–0.
Mississippi State Bulldogs vs. Notre Dame Fighting Irish: Mississippi State wins series 2–1.
Dallas Baptist Patriots vs. Virginia Cavaliers: Virginia wins series 2–1.
Tennessee Volunteers vs. LSU Tigers: Tennessee wins series 2–0.
The higher seeded team of each series hosted all three games.
