The 2022 United States Senate election in Pennsylvania was held on November 8, 2022, to elect a member of the United States Senate to represent the Commonwealth of Pennsylvania. Democratic lieutenant governor John Fetterman won his first term in office, defeating Republican surgeon Mehmet Oz. Fetterman succeeded incumbent Republican senator Pat Toomey, who did not seek re-election after two terms. The election marked the only U.S. Senate seat to flip parties in the 2022 midterms. In the May 17 primary, Fetterman won the Democratic nomination with 59% of the vote. Oz finished with a 0.1% difference ahead of businessman David McCormick in the Republican primary, triggering an automatic recount. McCormick conceded the nomination on June 3, making Oz the first Muslim candidate to be nominated by either major party for U.S. Senate. The general election was among the most competitive of the 2022 midterms and characterized as highly contentious. Fetterman framed Oz as an elitist carpetbagger with a radical anti-abortion stance in the wake of Roe v. Wade being overturned, while Oz framed Fetterman as a socialist insufficiently committed to fighting crime. Fetterman's health was also a major issue due to him suffering a stroke days before his primary victory. Although Fetterman led most pre-election polls, concerns towards his health and a scrutinized debate performance helped Oz take a narrow lead before the election. Despite Oz's lead in final polls, Fetterman won by a 5% margin, helping provide Senate Democrats a net gain of one seat and their first outright majority since 2015. With Fetterman's victory, elected Democrats held both Pennsylvania Senate seats for the first time since 1947.