Sean O'Brien is an American labor leader who is the General President of the International Brotherhood of Teamsters. He formerly served as the Vice President Eastern Region of the International Brotherhood of Teamsters (IBT). O'Brien was the youngest person elected as President of Teamsters Local Union 25 and was the Secretary-Treasurer of New England Joint Council 10. O'Brien resigned from Local 25 and Joint Council 10 on March 1, 2022, in order to serve full-time as General President of the International Brotherhood of Teamsters. O'Brien was sworn into office as the 11th General President of the International Brotherhood of Teamsters at the union's headquarters in Washington, D.C. on March 22, 2022.