Overview

• The study analyzed over 246 million patient records from the Epic Cosmos dataset and clinical databases in the United States and Lebanon.
• Gestational hypertension affects nearly 16% of U.S. pregnancies and is already known to increase risks of preterm birth and other complications.
• Children born to mothers with high blood pressure during pregnancy experienced significantly higher seizure rates, with male offspring showing the greatest vulnerability.
• Complementary mouse models confirmed that prenatal hypertension raises seizure sensitivity and seizure-related mortality in offspring.
• Findings suggest that targeting neuroinflammation with anti-inflammatory drugs could offer a new preventive strategy against seizures in exposed children.